11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). In vivo, 11β-HSD1 catalyzes the...

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Detalhes bibliográficos
Main Authors: Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Glucocorticoids-CRH-ACTH-Adrenal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279737/
https://ncbi.nlm.nih.gov/pubmed/22067318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1398
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