11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). In vivo, 11β-HSD1 catalyzes the...

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Autors principals: Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Glucocorticoids-CRH-ACTH-Adrenal
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279737/
https://ncbi.nlm.nih.gov/pubmed/22067318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1398
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