11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). In vivo, 11β-HSD1 catalyzes the...

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Bibliografiske detaljer
Main Authors: Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2012
Fag:
Glucocorticoids-CRH-ACTH-Adrenal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279737/
https://ncbi.nlm.nih.gov/pubmed/22067318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1398
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