11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). In vivo, 11β-HSD1 catalyzes the...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2012
Ämnen:
Glucocorticoids-CRH-ACTH-Adrenal
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279737/
https://ncbi.nlm.nih.gov/pubmed/22067318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1398
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk