Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1

Glucocorticoids (GC) are implicated in the development of metabolic syndrome, and patients with GC excess share many clinical features, such as central obesity and glucose intolerance. In patients with obesity or type 2 diabetes, systemic GC concentrations seem to be invariably normal. Tissue GC con...

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Hauptverfasser: Lavery, Gareth G., Zielinska, Agnieszka E., Gathercole, Laura L., Hughes, Beverly, Semjonous, Nina, Guest, Phillip, Saqib, Khalid, Sherlock, Mark, Reynolds, Gary, Morgan, Stuart A., Tomlinson, Jeremy W., Walker, Elizabeth A., Rabbitt, Elizabeth H., Stewart, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Glucocorticoids-CRH-ACTH-Adrenal
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475725/
https://ncbi.nlm.nih.gov/pubmed/22555437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1019
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