Formation of Threohydrobupropion from Bupropion Is Dependent on 11β-Hydroxysteroid Dehydrogenase 1

Bupropion is widely used for treatment of depression and as a smoking-cessation drug. Despite more than 20 years of therapeutic use, its metabolism is not fully understood. While CYP2B6 is known to form hydroxybupropion, the enzyme(s) generating erythro- and threohydrobupropion have long remained un...

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Библиографические подробности
Главные авторы: Meyer, Arne, Vuorinen, Anna, Zielinska, Agnieszka E., Strajhar, Petra, Lavery, Gareth G., Schuster, Daniela, Odermatt, Alex
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876805/
https://ncbi.nlm.nih.gov/pubmed/23804523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052936
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