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Ligand-Based Pharmacophore Modeling and Virtual Screening for the Discovery of Novel 17β-Hydroxysteroid Dehydrogenase 2 Inhibitors

[Image: see text] 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into estrone. This enzyme is expressed only in a few tissues, and therefore its inhibition is considered as a treatment option for osteoporosis to ameliorate estrogen deficiency. In this study, li...

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Main Authors: Vuorinen, Anna, Engeli, Roger, Meyer, Arne, Bachmann, Fabio, Griesser, Ulrich J., Schuster, Daniela, Odermatt, Alex
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111740/
https://ncbi.nlm.nih.gov/pubmed/24960438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5004914
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