Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole

Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease. Furthermore, placental 11β-HSD2 essentially protects the fetus from high maternal glucocorticoid levels, and its impaired function...

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Publicat a:Biochem Pharmacol
Autors principals: Beck, Katharina R., Bächler, Murielle, Vuorinen, Anna, Wagner, Sandra, Akram, Muhammad, Griesser, Ulrich, Temml, Veronika, Klusonova, Petra, Yamaguchi, Hideaki, Schuster, Daniela, Odermatt, Alex
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828556/
https://ncbi.nlm.nih.gov/pubmed/28131847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.01.010
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