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11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) t...

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Main Authors: Morgan, Stuart A., Sherlock, Mark, Gathercole, Laura L., Lavery, Gareth G., Lenaghan, Carol, Bujalska, Iwona J., Laber, David, Yu, Alice, Convey, Gemma, Mayers, Rachel, Hegyi, Krisztina, Sethi, Jaswinder K., Stewart, Paul M., Smith, David M., Tomlinson, Jeremy W.
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768185/
https://ncbi.nlm.nih.gov/pubmed/19675138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0525
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