11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) t...

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Auteurs principaux: Morgan, Stuart A., Sherlock, Mark, Gathercole, Laura L., Lavery, Gareth G., Lenaghan, Carol, Bujalska, Iwona J., Laber, David, Yu, Alice, Convey, Gemma, Mayers, Rachel, Hegyi, Krisztina, Sethi, Jaswinder K., Stewart, Paul M., Smith, David M., Tomlinson, Jeremy W.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2009
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768185/
https://ncbi.nlm.nih.gov/pubmed/19675138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0525
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