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The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function

α- and β-neurexins (NRXNs) are transmembrane cell adhesion proteins that localize to pre-synaptic membranes in neurons and interact with the post-synaptic neuroligins (NLGNs). Their gene mutations are associated with the autistic spectrum disorders. The extracellular region of α-NRXNs, containing ni...

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Detalhes bibliográficos
Main Authors: Miller, Meghan T., Mileni, Mauro, Comoletti, Davide, Stevens, Raymond C., Harel, Michal, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279696/
https://ncbi.nlm.nih.gov/pubmed/21620717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.03.011
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