Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells

OBJECTIVE: Pertussis toxin uncoupling–based studies have shown that Gαi and Gαo can inhibit insulin secretion in pancreatic β-cells. Yet it is unclear whether Gαi and Gαo operate through identical mechanisms and how these G-protein–mediated signals inhibit insulin secretion in vivo. Our objective is...

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Detalhes bibliográficos
Main Authors: Zhao, Aizhen, Ohara-Imaizumi, Mica, Brissova, Marcella, Benninger, Richard K.P., Xu, Yanwen, Hao, Yuhan, Abramowitz, Joel, Boulay, Guylain, Powers, Alvin C., Piston, David, Jiang, Meisheng, Nagamatsu, Shinya, Birnbaumer, Lutz, Gu, Guoqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279551/
https://ncbi.nlm.nih.gov/pubmed/20622165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1719
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