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High-affinity fluorescent ligands for the 5-HT(3) receptor

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.

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Bibliografiska uppgifter
Huvudupphovsmän: Simonin, Jonathan, Vernekar, Sanjeev Kumar V., Thompson, Andrew J., Hothersall, J. Daniel, Connolly, Christopher N., Lummis, Sarah C.R., Lochner, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier Science Ltd 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277886/
https://ncbi.nlm.nih.gov/pubmed/22189135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.11.097
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