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Varenicline Interactions at the 5-HT(3) Receptor Ligand Binding Site are Revealed by 5-HTBP

[Image: see text] Cys-loop receptors are the site of action of many therapeutic drugs. One of these is the smoking cessation agent varenicline, which has its major therapeutic effects at nicotinic acetylcholine (nACh) receptors but also acts at 5-HT(3) receptors. Here, we report the X-ray crystal st...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Price, Kerry L., Lillestol, Reidun K., Ulens, Chris, Lummis, Sarah C.R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505686/
https://ncbi.nlm.nih.gov/pubmed/25648658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500369h
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