Toward Biophysical Probes for the 5-HT(3) Receptor: Structure−Activity Relationship Study of Granisetron Derivatives

[Image: see text] This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT(3)A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identificati...

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Detalhes bibliográficos
Main Authors: Vernekar, Sanjeev Kumar V., Hallaq, Hasan Y., Clarkson, Guy, Thompson, Andrew J., Silvestri, Linda, Lummis, Sarah C. R., Lochner, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166935/
https://ncbi.nlm.nih.gov/pubmed/20146481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901827x
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