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Strand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEET

MitoNEET is a recently identified diabetes drug target that coordinates a transferable 2Fe-2S cluster, and additionally contains an unusual strand swap. In this manuscript, we use a dual basin structure-based model to predict and characterize the folding and functionality of strand swapping in mitoN...

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Bibliographic Details
Main Authors: Baxter, Elizabeth Leigh, Jennings, Patricia A., Onuchic, José N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277509/
https://ncbi.nlm.nih.gov/pubmed/22308404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116369109
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