Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys coordination of mNT’s [2Fe-2S] leads to cluster lability that is strongly dependent on the presence of the single histidine liga...

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Autors principals: Zuris, John A., Harir, Yael, Conlan, Andrea R., Shvartsman, Maya, Michaeli, Dorit, Tamir, Sagi, Paddock, Mark L., Onuchic, José N., Mittler, Ron, Cabantchik, Zvi Ioav, Jennings, Patricia A., Nechushtai, Rachel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156153/
https://ncbi.nlm.nih.gov/pubmed/21788481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109986108
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