The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer

Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S proteins...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bai, Fang, Morcos, Faruck, Sohn, Yang-Sung, Darash-Yahana, Merav, Rezende, Celso O., Lipper, Colin H., Paddock, Mark L., Song, Luhua, Luo, Yuting, Holt, Sarah H., Tamir, Sagi, Theodorakis, Emmanuel A., Jennings, Patricia A., Onuchic, José N., Mittler, Ron, Nechushtai, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378444/
https://ncbi.nlm.nih.gov/pubmed/25762074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502960112
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