The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer

Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S proteins...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Bai, Fang, Morcos, Faruck, Sohn, Yang-Sung, Darash-Yahana, Merav, Rezende, Celso O., Lipper, Colin H., Paddock, Mark L., Song, Luhua, Luo, Yuting, Holt, Sarah H., Tamir, Sagi, Theodorakis, Emmanuel A., Jennings, Patricia A., Onuchic, José N., Mittler, Ron, Nechushtai, Rachel
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378444/
https://ncbi.nlm.nih.gov/pubmed/25762074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502960112
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