Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors

N-methyl-d-aspartate receptors (NMDARs) mediate critical CNS functions, whereas excessive activity contributes to neuronal damage. At physiological glycine concentrations, NMDAR currents recorded from cultured rodent hippocampal neurons exhibited strong desensitization in the continued presence of N...

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Detalhes bibliográficos
Main Authors: You, Haitao, Tsutsui, Shigeki, Hameed, Shahid, Kannanayakal, Thomas J., Chen, Lina, Xia, Peng, Engbers, Jordan D. T., Lipton, Stuart A., Stys, Peter K., Zamponi, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277185/
https://ncbi.nlm.nih.gov/pubmed/22307640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110789109
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