Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

ABSTRACT: N-Methyl-d-aspartate (NMDA) receptors mediate a wide range of important nervous system functions. Conversely, excessive NMDA receptor activity leads to cytotoxic calcium overload and neuronal damage in a wide variety of CNS disorders. It is well established that NMDA receptors are tightly...

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Bibliografiske detaljer
Main Authors: Stys, Peter K, You, Haitao, Zamponi, Gerald W
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2012
Fag:
Symposium Section Reviews: Ion Channel Signalling Mechanisms
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382327/
https://ncbi.nlm.nih.gov/pubmed/22310309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.225276
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