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Mutation of copper binding sites on cellular prion protein abolishes its inhibitory action on NMDA receptors in mouse hippocampal neurons
We have previously reported that cellular prion protein (PrP(C)) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mouse hippocampal neurons in primary cultures from PrP null mice to determine the role of...
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| Vydáno v: | Mol Brain |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8287767/ https://ncbi.nlm.nih.gov/pubmed/34281567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00828-0 |
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