Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors

N-methyl-d-aspartate receptors (NMDARs) mediate critical CNS functions, whereas excessive activity contributes to neuronal damage. At physiological glycine concentrations, NMDAR currents recorded from cultured rodent hippocampal neurons exhibited strong desensitization in the continued presence of N...

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Bibliografski detalji
Glavni autori: You, Haitao, Tsutsui, Shigeki, Hameed, Shahid, Kannanayakal, Thomas J., Chen, Lina, Xia, Peng, Engbers, Jordan D. T., Lipton, Stuart A., Stys, Peter K., Zamponi, Gerald W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277185/
https://ncbi.nlm.nih.gov/pubmed/22307640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110789109
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