Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors

N-methyl-d-aspartate receptors (NMDARs) mediate critical CNS functions, whereas excessive activity contributes to neuronal damage. At physiological glycine concentrations, NMDAR currents recorded from cultured rodent hippocampal neurons exhibited strong desensitization in the continued presence of N...

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Bibliographic Details
Main Authors: You, Haitao, Tsutsui, Shigeki, Hameed, Shahid, Kannanayakal, Thomas J., Chen, Lina, Xia, Peng, Engbers, Jordan D. T., Lipton, Stuart A., Stys, Peter K., Zamponi, Gerald W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277185/
https://ncbi.nlm.nih.gov/pubmed/22307640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110789109
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