Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin

Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs “uphill” across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic, proton-driven transporter distantly related to the proton pump bact...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Ruivo, Raquel, Bellenchi, Gian Carlo, Chen, Xiong, Zifarelli, Giovanni, Sagné, Corinne, Debacker, Cécile, Pusch, Michael, Supplisson, Stéphane, Gasnier, Bruno
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277178/
https://ncbi.nlm.nih.gov/pubmed/22232659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115581109
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