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Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin

Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs “uphill” across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic, proton-driven transporter distantly related to the proton pump bact...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ruivo, Raquel, Bellenchi, Gian Carlo, Chen, Xiong, Zifarelli, Giovanni, Sagné, Corinne, Debacker, Cécile, Pusch, Michael, Supplisson, Stéphane, Gasnier, Bruno
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277178/
https://ncbi.nlm.nih.gov/pubmed/22232659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115581109
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