Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin

Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs “uphill” across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic, proton-driven transporter distantly related to the proton pump bact...

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Bibliographic Details
Main Authors: Ruivo, Raquel, Bellenchi, Gian Carlo, Chen, Xiong, Zifarelli, Giovanni, Sagné, Corinne, Debacker, Cécile, Pusch, Michael, Supplisson, Stéphane, Gasnier, Bruno
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277178/
https://ncbi.nlm.nih.gov/pubmed/22232659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115581109
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