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Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs “uphill” across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic, proton-driven transporter distantly related to the proton pump bact...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277178/ https://ncbi.nlm.nih.gov/pubmed/22232659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115581109 |
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