Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin

Secondary active transporters use electrochemical gradients provided by primary ion pumps to translocate metabolites or drugs “uphill” across membranes. Here we report the ion-coupling mechanism of cystinosin, an unusual eukaryotic, proton-driven transporter distantly related to the proton pump bact...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ruivo, Raquel, Bellenchi, Gian Carlo, Chen, Xiong, Zifarelli, Giovanni, Sagné, Corinne, Debacker, Cécile, Pusch, Michael, Supplisson, Stéphane, Gasnier, Bruno
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277178/
https://ncbi.nlm.nih.gov/pubmed/22232659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115581109
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