Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy

Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member of a family of heptahelical membrane proteins related to bacteriorhodopsin and characterized by a duplicated motif termed the PQ loop. PQ-loop proteins are more frequent in eukaryotes than in prokaryotes; exce...

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Detalhes bibliográficos
Main Authors: Jézégou, Adrien, Llinares, Elisa, Anne, Christine, Kieffer-Jaquinod, Sylvie, O’Regan, Seana, Aupetit, Joëlle, Chabli, Allel, Sagné, Corinne, Debacker, Cécile, Chadefaux-Vekemans, Bernadette, Journet, Agnès, André, Bruno, Gasnier, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528584/
https://ncbi.nlm.nih.gov/pubmed/23169667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211198109
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