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Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington’s Disease Model
Huntington’s disease is a neurodegenerative disorder resulting from expansion of a polyglutamine tract in the Huntingtin protein. Mutant Huntingtin forms intracellular aggregates within neurons, although it is unclear whether aggregates or more soluble forms of the protein represent the pathogenic s...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Genetics Society of America
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276644/ https://ncbi.nlm.nih.gov/pubmed/22095086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.133710 |
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