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The biological function of the Huntingtin protein and its relevance to Huntington’s Disease pathology

Huntington’s Disease is an adult-onset dominant heritable disorder characterized by progressive psychiatric disruption, cognitive deficits, and loss of motor coordination. It is caused by expansion of a polyglutamine tract within the N-terminal domain of the Huntingtin protein. The mutation confers...

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Detalhes bibliográficos
Main Authors: Schulte, Joost, Littleton, J. Troy
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237673/
https://ncbi.nlm.nih.gov/pubmed/22180703
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