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High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model
To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model. Drosophila primary neurons offer a sensitive readout for neurotoxicty, as their neurites develop dysmorphic features in...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166080/ https://ncbi.nlm.nih.gov/pubmed/21909362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023841 |
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