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The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants
EPAC is a cAMP-dependent guanine nucleotide exchange factor that serves as a prototypical molecular switch for the regulation of essential cellular processes. Although EPAC activation by cAMP has been extensively investigated, the mechanism of EPAC autoinhibition is still not fully understood. The s...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274826/ https://ncbi.nlm.nih.gov/pubmed/22325287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.030 |
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