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A Copper-Methionine Interaction Controls the pH-Dependent Activation of Peptidylglycine Monooxygenase
The pH dependence of native PHM and its M314H variant have been studied in detail. For WT PHM the intensity of the Cu-S interaction visible in the Cu(I) EXAFS data is inversely proportional to catalytic activity over the pH range 3 - 8. A previous model based on more limited data was interpreted in...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273323/ https://ncbi.nlm.nih.gov/pubmed/22080626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201193j |
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