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A Copper-Methionine Interaction Controls the pH-Dependent Activation of Peptidylglycine Monooxygenase

The pH dependence of native PHM and its M314H variant have been studied in detail. For WT PHM the intensity of the Cu-S interaction visible in the Cu(I) EXAFS data is inversely proportional to catalytic activity over the pH range 3 - 8. A previous model based on more limited data was interpreted in...

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Detalhes bibliográficos
Main Authors: Bauman, Andrew T., Broers, Brenda A., kline, Chelsey D., Blackburn, Ninian J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273323/
https://ncbi.nlm.nih.gov/pubmed/22080626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201193j
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