Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder in which the aggregation and deposition of amyloid-β (Aβ) peptides in the brain are central to its pathogenesis. In healthy brains, Aβ is effectively metabolized with little accumulation. Cellular uptake and s...

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Hauptverfasser: Kanekiyo, Takahisa, Zhang, Juan, Liu, Qiang, Liu, Chia-Chen, Zhang, Lijuan, Bu, Guojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272839/
https://ncbi.nlm.nih.gov/pubmed/21289173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5491-10.2011
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