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NSAID-Based γ-Secretase Modulators Do Not Bind to The Amyloid-β Polypeptide()
Gamma secretase modulators (GSMs) have received much attention as potential therapeutic agents for Alzheimer’s disease (AD). GSMs increase the ratio between short and long forms of the amyloid-β (Aβ) polypeptides produced by gamma-secretase and thereby decrease the amount of the toxic amyloid specie...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272834/ https://ncbi.nlm.nih.gov/pubmed/21995415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201371j |
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