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β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology
Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587707/ https://ncbi.nlm.nih.gov/pubmed/23208420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.167 |
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