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Ligand Binding and Structural Changes Associated with Allostery in Yeast NAD(+)-specific Isocitrate Dehydrogenase
Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octameric enzyme composed of four each of regulatory IDH1 and catalytic IDH2 subunits that share 42% sequence identity. IDH2 contains catalytic isocitrate/Mg(2+) and NAD(+) binding sites whereas IDH1 contains homologous binding sites, respec...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272323/ https://ncbi.nlm.nih.gov/pubmed/22008468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.10.003 |
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