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Basis for Half-Site Ligand Binding in Yeast NAD(+)-Specific Isocitrate Dehydrogenase

Yeast NAD(+)-specific isocitrate dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a catalytic IDH2 subunit and a regulatory IDH1 subunit. Despite structural predictions that the enzyme would contain eight isocitrate binding sites, four NAD(+) binding sit...

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書誌詳細
主要な著者: Lin, An-Ping, McAlister-Henn, Lee
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177981/
https://ncbi.nlm.nih.gov/pubmed/21861471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201088m
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