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Basis for Half-Site Ligand Binding in Yeast NAD(+)-Specific Isocitrate Dehydrogenase
Yeast NAD(+)-specific isocitrate dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a catalytic IDH2 subunit and a regulatory IDH1 subunit. Despite structural predictions that the enzyme would contain eight isocitrate binding sites, four NAD(+) binding sit...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177981/ https://ncbi.nlm.nih.gov/pubmed/21861471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201088m |
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