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Basis for Half-Site Ligand Binding in Yeast NAD(+)-Specific Isocitrate Dehydrogenase
Yeast NAD(+)-specific isocitrate dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a catalytic IDH2 subunit and a regulatory IDH1 subunit. Despite structural predictions that the enzyme would contain eight isocitrate binding sites, four NAD(+) binding sit...
Bewaard in:
| Hoofdauteurs: | , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177981/ https://ncbi.nlm.nih.gov/pubmed/21861471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201088m |
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