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Ligand Binding and Structural Changes Associated with Allostery in Yeast NAD(+)-specific Isocitrate Dehydrogenase

Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octameric enzyme composed of four each of regulatory IDH1 and catalytic IDH2 subunits that share 42% sequence identity. IDH2 contains catalytic isocitrate/Mg(2+) and NAD(+) binding sites whereas IDH1 contains homologous binding sites, respec...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsman: Lee, McAlister-Henn
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272323/
https://ncbi.nlm.nih.gov/pubmed/22008468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.10.003
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