Allosteric Motions in Structures of Yeast NAD(+)-specific Isocitrate Dehydrogenase

Mitochondrial NAD(+)-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative pathways in response to cellular energy levels. Here we present the first structures of a eukaryotic member of this enzyme family, the allosteric, hetero-octameric, NAD(+)-spe...

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Bibliographic Details
Main Authors: Taylor, Alexander B., Hu, Gang, Hart, P. John, McAlister-Henn, Lee
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447628/
https://ncbi.nlm.nih.gov/pubmed/18256028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708719200
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