Novel Functional MAR Elements of Double Minute Chromosomes in Human Ovarian Cells Capable of Enhancing Gene Expression

Double minute chromosomes or double minutes (DMs) are cytogenetic hallmarks of extrachromosomal genomic amplification and play a critical role in tumorigenesis. Amplified copies of oncogenes in DMs have been associated with increased growth and survival of cancer cells but DNA sequences in DMs which...

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Bibliographic Details
Main Authors: Jin, Yan, Liu, Zheng, Cao, Wei, Ma, Xinying, Fan, Yihui, Yu, Yang, Bai, Jing, Chen, Feng, Rosales, Jesusa, Lee, Ki-Young, Fu, Songbin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272018/
https://ncbi.nlm.nih.gov/pubmed/22319568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030419
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