Reducing system noise in copy number data using principal components of self-self hybridizations

Genomic copy number variation underlies genetic disorders such as autism, schizophrenia, and congenital heart disease. Copy number variations are commonly detected by array based comparative genomic hybridization of sample to reference DNAs, but probe and operational variables combine to create corr...

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Detalhes bibliográficos
Main Authors: Lee, Yoon-ha, Ronemus, Michael, Kendall, Jude, Lakshmi, B., Leotta, Anthony, Levy, Dan, Esposito, Diane, Grubor, Vladimir, Ye, Kenny, Wigler, Michael, Yamrom, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271883/
https://ncbi.nlm.nih.gov/pubmed/22207624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106233109
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