Reducing system noise in copy number data using principal components of self-self hybridizations

Genomic copy number variation underlies genetic disorders such as autism, schizophrenia, and congenital heart disease. Copy number variations are commonly detected by array based comparative genomic hybridization of sample to reference DNAs, but probe and operational variables combine to create corr...

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Autori principali: Lee, Yoon-ha, Ronemus, Michael, Kendall, Jude, Lakshmi, B., Leotta, Anthony, Levy, Dan, Esposito, Diane, Grubor, Vladimir, Ye, Kenny, Wigler, Michael, Yamrom, Boris
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271883/
https://ncbi.nlm.nih.gov/pubmed/22207624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106233109
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