Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

Histone deacetylases (HDACs) affect cell growth at the transcriptional level by regulating the acetylation status of nucleosomal histones. HDAC inhibition induces differentiation and/or apoptosis in transformed cells. We recently showed that HDAC inhibitors, such as suberoylanilide hydroxamic acid (...

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Main Authors: Mitsiades, Constantine S., Mitsiades, Nicholas S., McMullan, Ciaran J., Poulaki, Vassiliki, Shringarpure, Reshma, Hideshima, Teru, Akiyama, Masaharu, Chauhan, Dharminder, Munshi, Nikhil, Gu, Xuesong, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Richon, Victoria M., Marks, Paul A., Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC327183/
https://ncbi.nlm.nih.gov/pubmed/14695887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536759100
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