Molecular sequelae of proteasome inhibition in human multiple myeloma cells

The proteasome inhibitor PS-341 inhibits IκB degradation, prevents NF-κB activation, and induces apoptosis in several types of cancer cells, including chemoresistant multiple myeloma (MM) cells. PS-341 has marked clinical activity even in the setting of relapsed refractory MM. However, PS-341-induce...

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Detalhes bibliográficos
Main Authors: Mitsiades, Nicholas, Mitsiades, Constantine S., Poulaki, Vassiliki, Chauhan, Dharminder, Fanourakis, Galinos, Gu, Xuesong, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Treon, Steven P., Munshi, Nikhil C., Richardson, Paul G., Hideshima, Teru, Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137891/
https://ncbi.nlm.nih.gov/pubmed/12391322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202445099
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