Molecular sequelae of proteasome inhibition in human multiple myeloma cells

The proteasome inhibitor PS-341 inhibits IκB degradation, prevents NF-κB activation, and induces apoptosis in several types of cancer cells, including chemoresistant multiple myeloma (MM) cells. PS-341 has marked clinical activity even in the setting of relapsed refractory MM. However, PS-341-induce...

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Detaylı Bibliyografya
Asıl Yazarlar: Mitsiades, Nicholas, Mitsiades, Constantine S., Poulaki, Vassiliki, Chauhan, Dharminder, Fanourakis, Galinos, Gu, Xuesong, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Treon, Steven P., Munshi, Nikhil C., Richardson, Paul G., Hideshima, Teru, Anderson, Kenneth C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC137891/
https://ncbi.nlm.nih.gov/pubmed/12391322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202445099
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