Molecular sequelae of proteasome inhibition in human multiple myeloma cells

The proteasome inhibitor PS-341 inhibits IκB degradation, prevents NF-κB activation, and induces apoptosis in several types of cancer cells, including chemoresistant multiple myeloma (MM) cells. PS-341 has marked clinical activity even in the setting of relapsed refractory MM. However, PS-341-induce...

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Dades bibliogràfiques
Autors principals: Mitsiades, Nicholas, Mitsiades, Constantine S., Poulaki, Vassiliki, Chauhan, Dharminder, Fanourakis, Galinos, Gu, Xuesong, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Treon, Steven P., Munshi, Nikhil C., Richardson, Paul G., Hideshima, Teru, Anderson, Kenneth C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC137891/
https://ncbi.nlm.nih.gov/pubmed/12391322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202445099
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