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Asc Modulates the Function of NLRC4 in Response to Infection of Macrophages by Legionella pneumophila

Nucleotide-binding domain, leucine-rich repeat containing proteins (NLRs) activate caspase-1 in response to a variety of bacterium-derived signals in macrophages. NLR-mediated activation of caspase-1 by Legionella pneumophila occurs through both an NLRC4/NAIP5-dependent pathway and a pathway requiri...

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Bibliografske podrobnosti
Main Authors: Case, Christopher L., Roy, Craig R.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Microbiology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269931/
https://ncbi.nlm.nih.gov/pubmed/21771913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00117-11
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