Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and macrophages. Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(−/−) (Ipaf(−/−)), and caspase-1...

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Detalhes bibliográficos
Main Authors: Akhter, Anwari, Gavrilin, Mikhail A., Frantz, Laura, Washington, Songcerae, Ditty, Cameron, Limoli, Dominique, Day, Colby, Sarkar, Anasuya, Newland, Christie, Butchar, Jonathan, Marsh, Clay B., Wewers, Mark D., Tridandapani, Susheela, Kanneganti, Thirumala-Devi, Amer, Amal O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657210/
https://ncbi.nlm.nih.gov/pubmed/19343209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000361
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