A human cell-based reporter detects microhomology-mediated end joining

DNA double-strand breaks (DSBs) are most often repaired by two pathways in mammalian cells, homologous recombination or non-homologous end joining. Biochemical and genetic studies showed that DSBs can also be joined via microhomology-mediated end joining (MHEJ), which is always mutagenic and may res...

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Bibliografiske detaljer
Main Authors:	Liu, Yanguo, Deng, Li, Nguyen, Son C., Au, Catherine L., Shao, Changshun, Tischfield, Jay A., Liang, Li
Format:	Artigo
Sprog:	Inglês
Udgivet:	2011
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3268871/ https://ncbi.nlm.nih.gov/pubmed/22197482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2011.12.003
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A human cell-based reporter detects microhomology-mediated end joining

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