Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

DNA nonhomologous end-joining (NHEJ) and homologous recombination are two distinct pathways of DNA double-strand break repair in mammalian cells. Biochemical and genetic studies showed that DNA ends can also be joined via microhomology-mediated end joining (MHEJ), especially when proteins responsibl...

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Bibliographic Details
Main Authors: Liang, Li, Deng, Li, Nguyen, Son C., Zhao, Xin, Maulion, Christopher D., Shao, Changshun, Tischfield, Jay A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2425475/
https://ncbi.nlm.nih.gov/pubmed/18440984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn184
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