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Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining

In eukaryotes, DNA double-strand breaks (DSBs), one of the most harmful types of DNA damage, are repaired by homologous repair (HR) and nonhomologous end-joining (NHEJ). Surprisingly, in cells deficient for core classic NHEJ factors such as DNA ligase IV (Lig4), substantial end-joining activities ha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lu, Guangqing, Duan, Jinzhi, Shu, Sheng, Wang, Xuxiang, Gao, Linlin, Guo, Jing, Zhang, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747774/
https://ncbi.nlm.nih.gov/pubmed/26787905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521597113
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