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Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples

Background: Both common and rare mitochondrial DNA (mtDNA) variants may contribute to genetic susceptibility to some complex human diseases. Understanding of the role of mtDNA variants will provide valuable insights into the etiology of these diseases. However, to date, there have not been any large...

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Autors principals: Wang, Tao, Pradhan, Kith, Ye, Kenny, Wong, Lee-Jun, Rohan, Thomas E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Research Foundation 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268604/
https://ncbi.nlm.nih.gov/pubmed/22303347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2011.00051
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