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Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples

Background: Both common and rare mitochondrial DNA (mtDNA) variants may contribute to genetic susceptibility to some complex human diseases. Understanding of the role of mtDNA variants will provide valuable insights into the etiology of these diseases. However, to date, there have not been any large...

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Detalhes bibliográficos
Main Authors: Wang, Tao, Pradhan, Kith, Ye, Kenny, Wong, Lee-Jun, Rohan, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268604/
https://ncbi.nlm.nih.gov/pubmed/22303347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2011.00051
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