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Biases and Errors on Allele Frequency Estimation and Disease Association Tests of Next Generation Sequencing of Pooled Samples
Next generation sequencing is widely used to study complex diseases because of its ability to identify both common and rare variants without prior single nucleotide polymorphism (SNP) information. Pooled sequencing of implicated target regions can lower costs and allow more samples to be analyzed, t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477622/ https://ncbi.nlm.nih.gov/pubmed/22674656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21648 |
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